AT Gene Deficiency Increases Lung Cancer Risk
A study links lung cancer to a certain gene variation – alpha1-antitrypsin gene deficiency, which increases the risk for developing lung cancer.
A team of researchers from Mayo Clinic examined 1856 lung cancer patients, 902 brothers and sisters with healthy lungs, and 1585 healthy people with matching age, gender, and ethnicity. All participants were asked for blood samples and the samples were checked for gene variations.
Researchers found that there are some forms of defective alpha1-antitrypsin gene (AT gene) leading to lung cancer development.
The blood sample test results showed that those with alpha1-AT gene deficiency are 100% more likely to develop lung cancer, even if they are non-smokers. Researchers suggest that because of this gene deficiency lung tissue is vulnerable to damage. Damaged lung tissue itself can create favorable conditions for cancer to develop.